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Istituto Rinaldi Fontani · REAC Inside Blue Zone network

Microcirculation and longevity: why blood is not enough

8 May 2026 Prof. Dr Salvatore Rinaldi

Microcirculation and longevity: why blood is not enough

When we talk about circulation, we think of the large blood vessels. However, it is at the level of the microcirculation that the real exchange between blood and cells takes place. The microcirculation is responsible for distributing oxygen and nutrients to tissues.

When this system loses efficiency, the whole body is affected. Over time and in the presence of chronic stress, tissue perfusion can decrease, affecting cellular function and the recovery capacity of tissues. Inefficient microcirculation is not only a consequence of ageing, but one of its determining factors.

For this reason, longevity-oriented strategies place increasing emphasis on maintaining microcirculatory efficiency. Quality of life also depends on what happens in the smallest and least visible systems of our body.

In this context, clinical models such as REAC Inside Blue Zone apply this knowledge through protocols dedicated to supporting microcirculatory efficiency and tissue function.

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