reac longevity blog

Silent inflammation and neurodevelopment: Treating the “ground” to help children’s brains

Low-grade chronic inflammation may interfere with neurodevelopment in children with ADHD, autism and PANDAS. Learn how REAC IBZ protocols act on biological soil.

  • 15 May 2026
  • Drs. Giulio Viganò
Inflammation-silent-and-neurodevelopment

Inflammation is a natural and valuable response of our body. When we get injured or have an infection, it comes quickly and decisively, fights the problem and then runs out, like a fire that ignites and is tamed once the danger is resolved. The problem arises when this fire does not go out completely and becomes a constant and silent smoke: chronic low-grade inflammation, also called Low-Grade Chronic Inflammation or LGCI.

It does not cause striking symptoms, but over time profoundly alters the functioning of tissues and organs, including the brain. In the first years of life the brain is in full construction: It creates billions of connections every day, strengthening the useful ones and pruning the superfluous ones. Persistent inflammation acts as background noise that disrupts this delicate process of organisation.

How chronic inflammation can affect neurodevelopment

It is not the only cause, but chronic low-grade inflammation is an often underestimated factor that can worsen difficulties in neurodevelopment.

PANDAS/PANS

After some infections the immune system may overreact and attack areas of the brain involved in controlling behavior and movements: chronic inflammation may prolong this alert state.

ADHD

Inflammation can alter the dopaminergic and noradrenergic systems, making it more difficult to maintain attention, control impulses and regulate emotions.

Autism Spectrum Disorder (ASD)

Several studies have shown increased activation of microglia, the brain's immune cells: This state of perennial alertness can interfere with communication between neurons.

In summary, an inflamed environment makes the biological soil less conducive to the optimal development of the nervous system.

REAC technology: acting on the nervous system and biological “ground”

To address these challenges, REAC technology acts on two complementary levels. On the one hand, neuromodulation protocols (NPO, NPPO and CB) work directly on the regulation of the nervous system and adaptive responses. On the other hand, the new protocols Inside Blue Zone™ (IBZ) They focus on the biological “ground”, reducing chronic inflammation, improving circulation and supporting cellular energy.

The IBZ protocols: three steps to rebalance the cellular environment

ACT-IBZ – Regulation of the inflammatory cycle

It helps the immune system to properly complete the inflammatory cycles and return to a state of rest, favoring the conditions for a quieter brain environment.

CO-IBZ – Support for microcirculation

It improves microcirculation, allowing cells to receive better oxygen and nutrients and reducing oxidative stress that damages nerve connections.

MO-IBZ – Optimisation of cellular metabolism

It supports cellular metabolism, helping cells recover energy efficiency to better support development processes.

Look at the child as a whole

Neurodevelopmental disorders are complex and multifactorial. Looking also at chronic low-grade inflammation means considering the child as a whole: Not only the brain, but also the body that supports it.

Improving the biological soil is not a miraculous solution, but it creates the ideal conditions for the child's nervous system to develop in a more free, harmonious and stable way, allowing him to better express his evolutionary potential.

Drs. Giulio Viganò
Pediatrician – Milan

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